Showing posts with label 23andMe. Show all posts
Showing posts with label 23andMe. Show all posts

New and Innovative Ways to Help Find Unknown Ancestors


Several years ago I began to study the possibility of doing DNA testing with the ultimate goal of seeing if it could possibly help me to find my birth family.  I took a couple of courses on DNA at the local university and started reading everything I could get my hands on about DNA.

I contacted my good friend, Cece Moore, Your Genetic Genealogist, who I had been corresponding with for years on our genealogical connections. Cece has become the guru of DNA information and analysis combining it with her love of genealogy. And basically this combination is beginning to become the new innovative method of identifying unknown ancestors, whether you are adopted or not.

Before I get into the DNA angle, let me list some suggestions for adoptees. 

1. Put together a file with all the information you have on your birth and adoption, including copies of any birth or adoption documents that you may have and keep some kind of journal to record any progress.

2. Have you or are you working with anyone else to help them find your families? Occasionally we find that some adoptees have contacted other search angels who already have done some work. This prevents duplication of efforts.

3. Do you have non-identifying information provided by an agency?  If not, it is one of the first things you should try and get, if available. If you are unsure as to how to do that, we can help.

4. Are you registered with any state adoption registries? Have you posted your search to any online adoption registries or databases?

6. Depending on which state you were born and/or adopted in, you may already be eligible for original birth certificates or other information. Nineteen states do have some records open, either complete or partial. See list of states here: List of states with partial or full open records

We also recommend you join the yahoo group DNAadoption at Yahoo groups, an extremely active group with experts in all areas of DNA and adoptee searching.

What DNA tests should you do?

For males usually anything less than Y-DNA37 is essentially useless in identifying a surname. Males should have done at least Y-DNA37 unless they only have a few matches at a lower level.  If you already have done Y-DNA12 or Y-DNA25 and you have a number of matches, you should upgrade to at least Y-DNA37. Males should also do their autosomal DNA ("atDNA") (Family Finder at FTDNA; Relative Finder at 23andMe).

Females should have their atDNA done (Family Finder or Relative Finder).

For both males and females, we have found that Mitochondrial DNA is not real helpful because it's usually much too far back (1,000s of years). For adoptees, it will be rare to find a match to your biological family in recent generations using only mtDNA.  If you wish to have your mtDNA done you should have the Full mitochondrial sequence ("FMS") done.

If you have known living biological ancestors (such as you know your mother, but not your father) additional DNA tests should be done on those biological family members to help in possible phasing of your data (analyzing and recognizing the segments that are maternal vs. paternal) and possibly see other matches based on the randomness of DNA.

Once your test results are posted, you should download your raw data and upload to GEDmatch (http://www.gedmatch.com). Fishing in two ponds is better than one. Additional information and instructions to upload to Gedmatch can be found at http://www.dnaadoption.com

GEDmatch is a FREE, non-profit, “do-it-yourself” genomics website that allows DNA testers to upload raw data from FTDNA and other companies to compare with a large database of data that has been voluntarily uploaded by other testers.

My Tests

I had my DNA first tested at Family Tree DNA and also at 23andMe.  Both companies are recognized with state of the art testing, each has their pros and cons as I have discovered, but their analyses are well respected within the DNA community. I also more recently tested with AncestryDNA but that's another story for another blog post.  Nothing wrong there, they are just not geared to those of us who are interested in more detailed information regarding our results.  It can be helpful for some but since most adoptees have no idea of their ancestry, and have no family tree to link their results to, it may not be as helpful, unless you know at least some in your biological family and can post a tree to link your results.

For a female my only options were autosomal DNA ("atDNA") and/or mitochondrial DNA ("mtDNA").  At the time I was not well enough versed in which tests would give me the most bang for my buck, I opted to take the Family Finder (atDNA) plus mtDNA.  The 23andMe test automatically includes both, and Y-DNA for males. These tests are not cheap and spending $300 is not unusual. Sometimes FTDNA and 23andMe run sales which can save you at least 20% if not more.

The day finally came when my results were posted.  The dream of every adoptee is to have a 2nd cousin or better match on atDNA tests.  A 2nd cousin match would mean that you shared the same great grandparents.  As we only have a total of 8 great grandparents, this narrows down the field considerably of possible descendants who could be your birth parents.  The further back we go the more descendants to wade through. But I was beginning to realize that it was not impossible.....difficult and tedious? Yes, but the thought entered my mind.....why hasn't this been explored further? My years of work in genealogy was the perfect match for attempting something like this.  The skills I had learned could certainly be put to use in solving this mystery.

Next Step

I joined a few adoptee mailing lists. Eventually I found the awesome and extremely active DNAadoption at YahooGroups which had been recently started. Early on, not many of us were extremely well versed in DNA analysis but we all knew that this avenue of possibly solving the mysteries of our heritage was a new road we all wished to be traveling. Today there are close to 500 members of this group.  We have people who are experts in Ashkenazi Jewish ancestry, Y-DNA, German adoptions, search angels who comb records, and many others.  I contacted Cece and told her about it and said, "We could really use your help here."  She joined and has been one of our biggest assets and cheerleaders. We are all learning more and more and we all agreed that there definitely was a "method to our madness."

I also joined DNA-Newbie at YahooGroups moderated by Cece. Although not specifically geared towards adoptees, this list is a "must read" for anybody attempting DNA analysis. Another active mailing list is genealogy-dna@rootsweb.com which may address more complex matters regarding DNA but it is well worth putting on your reading list.  A great place to learn.

Each day I learn something new from the people on these lists. The subject matter on DNA is excruciatingly complex.  Many times I have to read an article 6 times for it to sink it. But the more I read, I realized that this intricate technology could be the latest innovation in finding my Foleys. The world of DNA is changing as we speak. Just in the last few months new discoveries and new methods are changing how scientists understand this once little known phenomenon.

Methods and tools are now being developed that will help adoptees in their searches. I met Rob Warthen on the AdoptionDNA list.  His expertise in programming and development along with his inspiration to help find his wife's birth family has led him to pioneer the development of tools and programs that has eased the process of retrieving DNA data and make it easier to manipulate. His website DNAGedcom.com is being developed to add these tools in a web based format. We all hope that 2013 will show a new growth of the use of these tools and programs with the ultimate goal of finding adoptees' place in their biological families.

What's Next

Cece Moore, Rob Warthen and I recently spoke at the 8th International Conference on Genetic Genealogy in Houston explaining the methodology.  It was well received and those of us involved are continuing to try and make it easier for adoptees to understand and use the tools. There is a light shining brightly at the end of that unknown tunnel and the methodologies have already been proven.  I expect that in the next year or two as new developments occur in the field of DNA we will begin to see a flood of questions answered for many adoptees.

Summary

The theory is simple - Find your DNA matches; Find others who match people on your list of matches by comparing chromosomal segments and overlaps; Find the ancestors of those matches; how they connect and work ancestral trees both linearly and laterally with the ultimate goal of finding your place in that family.

The execution is hard work, complex and tedious - but it can be done.  It has been done!

Suggested Reading

Richard Hill, one of my co-administrators at the Global Adoptee Genealogical Project at FTDNA, tells the story of his decades-long search for biological family and the innovative use of genetic genealogy DNA tests to identify his birth father. I highly recommend this well written book for anybody searching for their unknown ancestors.  http://www.FindingFamilyBook.com



Karin Corbeil/Carol Lee Foley
Daughter of Edward & Helen Rasmussen Baum and Robert & Barbara Foley Shumsky


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DNA to the Rescue.....Finding my Mother and now my Father!

To continue from my recent previous post in locating my birth mother.

I have been in contact with my birth family. I have a living full brother who is understandably overwhelmingly shocked. We will just take baby steps. The son of my birth mother's sister, a 1st cousin, has been extraordinarily welcoming and we have talked several times. He is putting together a box (a BOX!, not an envelope) of photos and other family memorabilia for me, including my mother's baptismal certificate and pictures of her from the time she was a child. My cousin and I have already developed a wonderful rapport and he has been totally supportive. But the question still nagged at me....Who was my father?

DNA was not the avenue that identified my mother but I am now confident that it has identified my father.

After a week of absorbing all the information, I finally went and checked my Polish DNA matches. I never knew what to do with them before I had at least a surname. My father was of Polish descent with a somewhat uncommon surname. At least it wasn't Kowalski - the Polish equivalent to "Smith"! My mother got pregnant at the age of 16, the facts are is that my father was 17. A year or two after I was born she married. And I totally believe she married the man who was my father.

In looking for his surname, I was able to determine that there were 2 of my matches on FTDNA, 1 match on 23andme and a 4th match on Gedmatch who all matched each other and they all have my father's surname in their ancestry. All of these matches were managed by the same person. She lives in Belarus and only speaks and writes Russian. The most recent common ancestor is probably back in the early to mid 1700's and we are probably no closer than 5th cousins. Needless to say, the challenges seem to be endless. Regardless, with my gut instinct and knowing a little bit more about my mother's history, the common surname and matches, the overlapping segments especially on Chromosomes #2, 3, 4 and 12, can only lead me to conclude one thing...the man that my mother married was also my father.

The screenshot below is from FTDNA chromosome browser of the two Family Finder matches from this family. Notice the nice overlaps on Chromosome 3 and 4. The other two matches from 23andme and Gedmatch also overlap at the same segment location!!!:



So I'm comfortable with my conclusion (or maybe I should say "confusion") that DNA has identified my father.

What's next you may ask? As I discover more, my "To do" list is never-ending. I believe I may also have some half-siblings, as my mother died young at the age of 32 in a car accident. My father remarried a few years later. I have been active, although on the fringe, of the Adoptee Rights movement and will definitely become more involved, especially in New York and here in South Carolina. Access to original birth certificates should be everyone's right...not a privilege. I will also continue to help other adoptees in their searches in any way I can possibly contribute.

A special thanks to all those who helped me in this continuing journey....you know who you are!

Karin Corbeil
-- born Carol Lee Foley in Brooklyn, NY
mother identified 6/14/2012

NEXT

BACK

It's that time of the year...

How caught up we all get this time of year....family, friends, parties, Christmas shopping. But the joy of the season sometimes gets left behind. I was thrilled last night to learn that one of my fellow adoptees found his birth family via DNA and to think the timing was so perfect for this time of year. His half-sister wrote "I got a baby brother (albeit a 45-year-old one) for Christmas this year!" It was truly God's gift to this family. (I get teary eyed every time I think about it.)

My research continues with a little progress each week. I now have surnames to work with! And with a few surprises in the mix. It's an amazing feeling, that only an adoptee can understand, to know that there are real flesh and blood people out there who you are related to. It may be a long road before I have all the answers, if ever, but I am confidently moving in the right direction.

Best wishes for a glorious holiday season and may 2012 all bring us the best of everything!

We're off to the Caribbean for a week with the family! Bon voyage.

Another Foley

I'm afraid Alice is going to have to take back seat for a while until I figure out my newest and latest DNA match who also happens to be a Foley!

After months of hoping, wishing and praying of getting a "Foley" match to my DNA, my prayers have been answered.

Last week a barrister from Dublin, Ireland wrote me whose surname is Foley. He had requested to share genomes (a genome is the entirety of an organism's hereditary information) at 23andMe (a genetic testing company...23andMe). We didn't show a match.

He suggested I join the Leinster project at Ancestor-Projects. I have small matches with 14 out of 16 people on that project. Then I went to Gedmatch (GEDmatch provides tools for making comparisons between genealogies and DNA test results) . He also was tested at FTDNA (FamilyTree DNA, also a genetic testing company...Family Tree DNA) and our FTDNA results do show a match. Somewhat small but with an MRCA (Most Recent Common Ancestor) of 6.7....meaning we may share maybe a common  4th or 5th great grandparent.

I'm currently analyzing common matches with him and some others that we both match....and there are quite a few.

This opens up some other options in that it gives me additional surnames....Cahill, Farrell, Callen, Carr and Neill. It also shows me where my Foley ancestors may have been originally from....County Kildare, Ireland.
Here are the match results:

Comparing FTDNA kit F20XXXX and F15XXXX results (MRCA 6.7 generations):
Chr  Start  End cMs SNPs
5 164.8 166.8 3.4 569
7 88.7 92.5 3.2 756
14 22.3 23.9 5.0 583
16 12.1 13.5 4.2 563
17 53.3 56.8 3.1 570

Total cMs 18.9 Longest 5.0
Total SNPs 3041

Comparing his other FTDNA kit 15XXXX with my FTDNA F20XXXX (MRCA 7.0):

Chr  Start  End cMs SNPs
9 21.9 25.7 5.0 368
10 55.4 60.6 3.8 327
11 42.4 58.1 5.3 418
11 85.1 91.3 3.7 391
14 22.3 25.6 7.6 351

Total cMs 20.4 Longest 7.6
Total SNPs 1855

Acronyms used and their definitions:
Chr = Chromosome - a structure in the nucleus containing a linear thread of DNA which transmits genetic information.

cMs = centimorgans - a unit of chromosome length where a spacing of one centimorgan indicates a one per cent chance that two genes will be separated by crossing over. Crossing over is a genetic operator that varies a chromosome's programming between generations.

SNPs = Single Nucleotide Polymorphism; a variation in the genetic code at a specific point on the DNA.

Start and End = where exactly on the Chromosome the match begins and ends.



I suppose that this is all Greek to most people....and it was to me at first.

Enough to say that there are lots of folks who are skeptical of these shorter matches. They say it could just be a false positive. However, many have proved it on paper enough times to think they are real.

Now, my question to all the experts out there. Based on the DNA comparison.....am I really related to him?

For the time being, until somebody tells me I'm wasting my time, I will continue to look for our common matches and hopefully discover someone with a well documented family tree and see if I can slip myself into it!



Posted November 22, 2011

Oh, and Happy Thanksgiving to all!!